Cytogenetic biodosimetry for radiation accidents in China

Radiation Dose Estimation by Automated Cytogenetic Biodosimetry.

The dose from ionizing radiation exposure can be interpolated from a calibration curve fit to the frequency of dicentric chromosomes (DCs) at multiple doses. As DC counts are manually determined, there is an acute need for accurate, fully automated biodosimetry calibration curve generation and analysis of exposed samples. Software, the Automated Dicentric Chromosome Identifier (ADCI), is presen...

Accurate cytogenetic biodosimetry through automated dicentric

Accurate digital image analysis of abnormal microscopic structures relies on high quality images and on minimizing the rates of false positive (FP) and negative objects in images. Cytogenetic biodosimetry detects dicentric chromosomes (DCs) that arise from exposure to ionizing radiation, and determines radiation dose received based on DC frequency. Improvements in automated DC recognition incre...

Serum microRNAs – potent biomarkers for radiation biodosimetry

An automated imaging system for radiation biodosimetry.

We describe here an automated imaging system developed at the Center for High Throughput Minimally Invasive Radiation Biodosimetry. The imaging system is built around a fast, sensitive sCMOS camera and rapid switchable LED light source. It features complete automation of all the steps of the imaging process and contains built-in feedback loops to ensure proper operation. The imaging system is i...

Practical applications of cytogenetic biodosimetry in radiological emergencies

The Fukushima nuclear disaster caused by the earthquake and tsunami on March 11, 2011 is believed to be the worst nuclear accident since the Chernobyl disaster in 1986. The Korean government is providing support to Japan and is also trying to protect the people from the hazards of ionizing radiation. To this end, Korean rescuers have been dispatched to the disaster-struck areas to assist in the...